Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides:Synthesis of 1, 4- dicarbonyl
compounds has been reported via chemoselective
activation of amide carbonyl functionality. An Umpolung reaction proceeds via
N-oxide addition generates an electrophilic enolonium species that can be
coupled with a wide range of nucleophilic enolates. The method avoids the use
of transition metal catalysts.
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